There are actually postmarketing reports of coma and Loss of life with coadministration of buprenorphine and benzodiazepines. In several, although not every one of these cases, buprenorphine was misused by self-injection. If a benzodiazepine should be utilized for an indication besides seizures, reduced the benzodiazepine First dose and cautiously titrate to clinical reaction.
fluconazole will raise the level or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
lapatinib will raise the amount or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
diazepam and olopatadine intranasal equally boost sedation. Avoid or Use Alternate Drug. Coadministration raises danger of CNS depression, which can result in additive impairment of psychomotor functionality and cause daytime impairment.
Abuse and misuse of benzodiazepines commonly require concomitant utilization of other medications, Alcoholic beverages, and/or illicit substances, that's connected with an increased frequency of significant adverse results; before prescribing and in the course of cure, assess each patient’s risk for abuse, misuse, and dependancy
dexamethasone will decrease the read more extent or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
lorlatinib will decrease the level or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
Coadministration of encorafenib with delicate CYP3A4 substrates may well result in increased toxicity or decreased efficacy of those brokers.
fentanyl iontophoretic transdermal method and diazepam both equally enhance sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative cure selections are insufficient
The standard precautions are indicated for seriously depressed patients or All those in whom There is certainly any evidence of latent despair or anxiety connected with melancholy, notably the recognition that suicidal tendencies may be current and protecting actions could possibly be necessary.
aprepitant will increase the amount or influence of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
Observe Carefully (1)istradefylline will enhance the amount or outcome of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
apalutamide will decrease the level or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with drugs that happen to be CYP3A4 substrates can result in lower publicity to those medications.
Drugs that have to have prior authorization. This restriction needs that specific clinical requirements be fulfilled previous to the acceptance on the prescription.